Effect of DA-9701 on gastric emptying in a mouse model: Assessment by13C-octanoic acid breath test
نویسندگان
چکیده
منابع مشابه
Assessment of gastric emptying in non-obese diabetic mice using a [13C]-octanoic acid breath test.
Gastric emptying studies in mice have been limited by the inability to follow gastric emptying changes in the same animal since the most commonly used techniques require killing of the animals and postmortem recovery of the meal(1,2). This approach prevents longitudinal studies to determine changes in gastric emptying with age and progression of disease. The commonly used [(13)C]-octanoic acid ...
متن کاملDelayed Gastric Emptying in Anorexic Adolescents Measured with the 13C Octanoic Acid Breath Test
Many gastrointestinal complaints and motility disorders are described in patients suffering from different eating disorders. These have a negative impact on refeeding. This report evaluated—on admission—gastric emptying of a standardized solid meal with C octanoic acid breath test in anorexic adolescents. The results were compared with age and gender matched controls. Gastric emptying data were...
متن کاملGastric emptying flow curves separated from carbon-labeled octanoic acid breath test results.
Recently, we developed the [13/14C]octanoic acid breath test to measure gastric emptying of solids. Although the method has been validated extensively, absorption, metabolism, and excretion of the label in the breath need to be corrected for. In this study a mathematical model was developed that allows for 1) separation of the global CO2 excretion after ingestion of the labeled test meal into t...
متن کاملBayesian Hierarchical Methods to Interpret the 13C-Octanoic Acid Breath Test for Gastric Emptying
BACKGROUND The (13)C-octanoic acid breath test is a convenient method for assessing gastric emptying (GE). Success depends on obtaining a well-characterized time profile of the excretion of label in breath, which may not be the case if GE is delayed. AIMS To use Bayesian techniques in conjunction with hierarchical modelling as a method to increase the success of the modelling process. METHO...
متن کاملC octanoic acid breath test
Although scintigraphy, a non-invasive procedure, is usually considered to be the reference technique for measuring gastric emptying in humans, several drawbacks limit its application in routine practice. Expensive equipment is required and access to a nuclear medicine department, and the use of radioactive isotopes (generally Tc and In) can produce low but significant irradiation. It is diYcult...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2013
ISSN: 1007-9327
DOI: 10.3748/wjg.v19.i27.4380